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High-speed and high-ratio referential genome compression

DARRC is a new alignment-free and reference-free compression method that addresses the problem of pan-genome compression by encoding the sequences of a pan-genome as a guided de Bruijn Graph. The novelty of this method is its ability to incrementally update DARRC archives with new genome sequences without full decompression of the archive. DARRC can compress both single-end and paired-end read sequences of any length using all symbols of the IUPAC nucleotide code.

Nascent Transcription Processing Pipeline

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